Of growth hormone a lot of talking, and this topic, in recent years, becoming more and more interesting to a wide range of athletes non-professionals. There are many questions on the use of growth Hormones to grow body mass, about the side effects of growth hormone, and also about the options and availability of this Hormones of growth in the Russian market. To these and other questions I tried to answer in this article. Those who are not interested in the technical side of the action of the hormone, you can skip to the second part of the article “the practical application of growth Hormones for non-medical purposes”.
Growth hormone and its mechanism of action. Growth hormone is a protein produced and secreted by the anterior lobe of the pituitary gland. Of all the hormones of the pituitary gland it is produced in the largest quantity. The formation and secretion of growth hormone regulates hypothalamic releasing hormone and somatostatin. Both of these factors are produced by the hypothalamus. Growth hormones is produced throughout life. Production of growth Hormones increases during growth of the organism, approximately, to 20 years and then decreases with age with an average rate of 14% per decade.
Function growth hormone. Growth hormones stimulates linear growth and the growth of internal organs. Causes an increase in the number and size of muscle cells, liver, thymus, gonads, adrenals and thyroid. Affects metabolism of proteins, fats and carbohydrates. Inhibits the activity of enzymes that destroy amino acids, increases the level of insulin-like growth factors I and II (IGF I and II) in blood serum, stimulates the synthesis of collagen in bones, skin, and other organs and tissues of the body. Growth hormone increases glucose output in the hepatic vein, increases gluconeogenesis (formation of glucose from non-carbohydrate precursors), reduces the absorption of glucose in the periphery, and also increases lipolysis (breakdown of fat), resulting in the blood increases the concentration of free fatty acids that inhibit insulin action on membrane transport of glucose.
The effect on protein synthesis. Growth hormone stimulates amino acid transport into muscle cells and, moreover, increases protein synthesis , regardless of the effect on amino acid transport. People receiving growth Hormones, there is a positive nitrogen balance, which reflects a General increase in protein synthesis and a decrease in the content of amino acids and urea in plasma and urine. These changes are accompanied by increased levels of synthesis of RNA and DNA in certain tissues. In this respect, destrie growth Hormones similar to some effects of insulin.
The influence on carbohydrate metabolism. In terms of impact on carbohydrate metabolism growth hormone is an antagonist of insulin. Hyperglycemia that occurs after administration of growth Hormones, the result of a combination of reduced peripheral glucose utilization and its increased production by the liver in the process of gluconeogenesis. Acting on the liver, growth Hormones increase the glycogen content in it, probably due to activation of gluconeogenesis from amino acids. Growth hormones can cause a disruption of certain stages of glycolysis (breakdown of glucose in tissues) and inhibit glucose transport. Inhibition of breakdown of glucose in muscle may be also associated with mobilization of fatty acids from triacylglycerols reserves.
Influence on lipid metabolism. Growth hormone has a powerful lipolytic effect. Increase lipolysis by increasing the mobilization of fat from depot that leads to a rapid increase in the concentration of free fatty acids in plasma and their oxidation in the liver. The energy generated during excessive fat breakdown, is used in the anabolic process in protein metabolism.
Regulation of secretion and synthesis. On the secretion of growth Hormones affects a number of stimuli (sleep, stress), and she, like the secretion of many pituitary hormones is episodic and pulsatile nature. Within a few minutes the level of growth Hormones in the plasma can change 10 times. One of the biggest peaks observed shortly after falling asleep, which confirms the saying: “Who does not sleep, he does not grow”. Other incentives include stress (pain, cold, anxiety, surgery), exercise, acute hypoglycemia or fasting, protein food or amino acid arginine. The possible Association of these and many other effectors with the main physiological effect growth Hormones, including the sbereganie glucose. Under stress, hypoglycaemia, and during sleep or fasting, the growth Hormone stimulates lipolysis (the delivery of fatty acids) and penetration into the cells amino acids (potential substrates of gluconeogenesis), thus preserving glucose for brain metabolism. On the release of growth Hormones is influenced by a variety of agents, including estrogen, dopamine, alpha-adrenergic compounds, serotonin, opioid polypeptides, hormones and gut glucagon. The point of application of the action of all these factors is the ventromedial nucleus of the hypothalamus, where regulate the secretion of growth hormone type of feedback. Short loop system involves positive (stimulating) the regulator of the secretion – somatoliberin and negative (inhibiting) regulator somatostatin.
Physiological and biochemical effects. Insulin-like growth factors (IGF). The growth-stimulating effect of growth Hormones determines primarily IGF-1, which is formed in the liver. IGF-1 regulates the secretion of growth Hormones, preventing the release somatoliberina and stimulating the release of somatostatin. IGF-1, a gene which belongs to the family of insulin-like genes, were originally known as “sulfureuse factor” due to its ability to stimulate the incorporation of sulfate into cartilage, later became somatomedin S. In structure it is similar to proinsulin. In the plasma of a human is detected, another related peptide – insulin-like growth factor 2. And IGF-1 and IGF-2 bind to membrane receptors, but they can be separated by specific radioimmunoassays. IGF-1 consists of 70 amino acids IGF-2 – 67. Despite the fact that the content of IGF-1 in plasma is less than half of the content of IGF-2, that IGF-1 shows a similarity with the effects of growth Hormones. Persons with a deficiency of IGF-1 that produce IGF-2 in sufficient numbers lack the capacity for normal growth. Insulin-like growth factors (IGF-1 and IGF-2) are not pancreatic hormones, but, nevertheless, close to insulin in structure and function. The effect of insulin on growth and replication (cell division) of cells is difficult to separate from similar effects from IGF-1 and IGF-2.
Indeed, insulin and insulin-like growth factors may interact in this process. Insulin has a stronger effect on metabolism than insulin-like growth factors, but the latter is stronger stimulate cell growth. Each of these hormones has its specific receptor. These hormones are able to some extent cross-contact receptors than, perhaps, explains their inherent combined biological activity. IGF-1 and IGF-2 are single chain polypeptides with 70 and 67 amino acids, respectively. The degree of correspondence between these two hormones reaches 62% and 50% of amino acid residues in each of them identical to those for insulin. The molecules of these growth factors have different antigenic sites and are differentially regulated. IGF-I stimulates the growth of cartilage and the number of processes in the cartilage tissue: the transport of amino acids, synthesis of RNA, DNA, protein, chondro-Itin sulfate, collagen. Growth factors also exhibit insulin-like activity in the muscles is stimulation of transport of amino acids (this process is much faster under the influence of the FMI than under the influence of growth hormone) and glucose, collagen formation, protein synthesis; adipose tissue – stimulation of glucose transport, oxidation of glucose to co, and the incorporation of glucose into lipids, and the suppression of lipolysis (similar to the mechanism of action of insulin). Thus, growth hormone carries out biological effects through the formation of somatomedines (IGF-1 and IGF-2), which are formed in the liver and other peripheral tissues and mediate anabolic growth effects of growth hormone. The latter exert their action Through hormonal, paracrine or autocrine mechanisms.
Practical application of growth hormone for non-medical purposes.
After reading basically the same article about growth Hormones is known to hyped and not very good sites, I have come to believe that the Internet of accurate information about the use of hormone almost none. A variety of literature such Bulanov, sold in sports shops, also raises doubts, one only has to pick up a good reference book on medicine, so as always have to eksperimentirovat. Having experienced the effect of growth Hormones in different dosages and combinations, I came to the belief that growth Hormones do is a powerful drug for lean muscle mass and reduce body fat. However, in order to achieve the impressive results when taking human growth Hormone by binding a number of conditions to abide by which may only very eHarmony romancey range of people. And it’s not even about the money, it’s in Your Hormones rastavica of life that needs to be completely subordinated to nutrition, training and … injections, that simply may not be compatible with work and other life conditions of the many. In advance, we note that to properly and effectively use growth Hormones can high level athletes training with a lot of experience not only training, but also the use of other doping means. For example, an ordinary rocking, dreaming of the biceps at 45-47 cm (and possibly more) do not think about the immediate use of growth Hormones, he can get what you want and when using other drugs, everything takes time and effort, although if any athlete begins to build your Hormones restavek training, nutrition, and concomitant medications, if possible, to use growth Hormones such athlete will be able to get a much larger result.
Dosage. So, what is the rate of growth hormone? Drug activity determined by biological methods and expressed in the unit of (ED). In professional sports the growth hormone is used very widely, for example doses of athletes ranging from 4 to 8 IU a day, which is not enough to set out of the ordinary muscle mass. Growth hormone has a strong anabolic effect and when using it there is hyperplasia of cells of organs and tissues (an increase in the number of structural elements of cells because of their excess education). This effect is certainly the most important for bodybuilders, can arise only at relatively long-term use of growth Hormones in large doses. Course duration should be not less than 3 months, and the dosage of not less than 12-16 UNITS per day, administered over 2-3 injections. Such dosages are needed for rapid hypertrophy of muscle cells leading, in turn, by the hyperplasia of these cells. With the use of lower dosages of these processes are too slow, that was a really powerful increase in lean body mass. It should be remembered that receptors quickly get used to the hormone and inject it too long is also not necessary, and that is why growth Hormones should be taken in large doses. The course can last 3-4 months, followed by a rest equal to the length of the course, in the first half which will still experience a strong enough effects of the hormone. Of course, growth Hormones can be taken for six months or more, but in small doses 2-4 IU per day, then the buds will be much slower to get used to, but it is achieved with a full effect of hypertrophy and hyperplasia of muscle cells is almost impossible. Dosage to 10 a day, not for bodybuilders, if they are really ambitious.
Related drugs. Now another very important point – the drugs used in combination with growth Hormones. I would like to remind you, if someone else did not understand what we are talking about the use of growth Hormones for the purpose of Hyper growth muscle mass. For such growth required for maximum stimulation of the body and one growth Hormones for this little. In addition, there are reasons for the inclusion in therapy of growth Hormones other hormonal methods, but all in order. Everyone has heard about the scheme: growth hormone + anabolic and androgenic steroids + insulin + thyroid thyroid hormones, such as triiodothyronine (online it is called cytomel, but this drug is not). With the growth hormone is more or less clear, so go to a/a steroids
Of course, steroids should be included in the complex, because having a potent anabolic properties, they usilivaet hypertrophy of muscle cells, which, of course, will faster lead to hyperplasia of cells exposed to growth Hormones. Now, let’s discuss insulin. Something where you can hear the insulin in any case can not be used in conjunction with growth Hormones, or so the commercials, but this is not so. Moreover, insulin almost definitely need to take if your dosage of growth Hormones is really high. The fact is that the excess of somatotropic hormone in the body contributes to the function of the beta cells of the pancreas, hyperplasia and the depletion of reserve capacity, which leads to the development of diabetes. But here it should be noted that to fall ill with diabetes is possible only with a very long therapy growth Hormones. It is unlikely that courses with a length of 3-4 months will lead to such an effect, an exception may be only persons who have a genetic predisposition to diabetes, or already suffering from mild stages of diabetes. In all cases the use of insulin is necessary, but the means of insulin administration is to be different from ordinary use for the growth of the mass. Insulin is needed to facilitate ngermany rostowski on the pancreas, which under the influence of growth Hormones, as has been said, begins very active work and Deplete their reserves. Therefore, to effectively inject insulin before each meal for 6-8 MEALS. Moreover, insulin, as well possessing the ability to enhance the anabolic impact on muscle cells, further accelerates their growth. Let’s talk about the thyroid hormones. In small doses, thyroid hormones also have anabolic action, expressed in the acceleration of metabolism (increase consumption of all prijatelne substances – carbohydrates, fats, proteins) and the stimulation of tissue growth. Although you need to remember one thing – in high doses of t-hormones contribute to the opposite effect, i.e. strengthening the catabolic processes of protein degradation in muscle cells. Professional sportmen include in cycle thyroid hormones not because of their effect on growth, but rather due to exposure to large doses of growth Hormones in the gland function. Effects on the thyroid hyperplasia is expressed in cells of the gland and as a consequence increasing its size. People suffering from acromegaly (excessive production of endogenous growth hormone), during the years of disease, perhaps a strong enough increase in the size of the thyroid gland with changes in its functions or unchanged. Therefore, the use of growth Hormones in large doses can lead to inhibition of thyroid function with the development of symptoms of hypothyroidism. In principle, a periodic monitoring of the functional state of the thyroid gland and the reception of thyroid preparations. As a rule, athletes use large doses of growth Hormones, taking 50 mcg of triiodothyronine per day for two doses. To start the reception should be no more than 25 mcg per day and increase to 50 mcg in 7-10 days. Large doses are not advised, as already noted, this can lead to loss of muscle mass. So, if your plans of increasing muscle mass so ambitious and you have decided to use growth hormone, it must be remembered that when large doses of growth Hormones are able to stimulate powerful muscle growth, it is also necessary the use of other hormones, not only due to the strengthening effect, but also the safety of your body.
Side effects. Side effects when using growth Hormone can be different depending on dosage, time of administration and characteristics of the organism. Possible headache, increased intracranial pressure, nausea, edema syndrome, hyperglycemia (elevated glucose level in the blood), local reactions – changes the amount of adipose tissue (you have to change the place of subcutaneous injection in connection with the possibility of lipoatrophy, combustion of fat). The effects of long-term overdose: depression of thyroid function with the development of symptoms of hypothyroidism (decreased production of t hormones by the thyroid gland), impaired function of the pancreas with the possibility of development of diabetes, increased growth of not only soft tissue but also cartilage and bone, resulting in enlargement of facial features, increase in size of upper and lower extremities. With open areas of growth (20-25 years) possible linear growth of the body.
Other times. As always, we note that the basis of any growth lies with proper and sufficient food. Metabolic processes are so badly twisted under the influence of growth Hormones and related drugs, 5 meals a day not to be missed for serious growth. 8 meals that are high in protein, carbohydrates, and fats provide all the necessary for accelerated growth of the muscle mass of the body under the impact of the scheme growth Hormones+insulin+thyroid+steroids. The body’s need for food should be met at least 1 time 1.5-2 hours. In this mode there is a feeling of almost continuous eating of food, but it will be a major part of Your growth. The basis of the daily diet is the food from the market, i.e. fresh meat, eggs, dairy products, cereals, vegetables, etc. On admission, dry mixes and other additives, sold in sports shops, think only in the last instance. With the exception of vitamin-mineral complexes, because even with a strong desire you will not gain all the required for your body to connections only from healthy food. Taking vitamins and minerals is mandatory.
Conclusion. Growth hormone is an amazing and powerful drug that can serve different purposes. In any case, the dosage and duration of use are crucial. You should not rely on any real muscle growth using dosage of 4 IU per day, most often it is so much advised to use the sellers of fakes. While it will not be possible to fully secure a sufficient amount of the drug, you should not be taken for the use of growth Hormones in order to increase muscle mass. It is also important the use of growth Hormones and other drugs, without which not only fail to achieve high results, but you can earn a chronic illness. So, all you need to be careful not to trust the first word of some pitching, which stands behind the counter of a sports store, and advertises the goods of his employer.